My Google Page Rank

Study digs into secrets of keeping HIV in check

PDFPrintE-mail

A small number of HIV-infected patients have immune systems that are able to keep AIDS at bay by preventing the virus from reproducing for years, and researchers are reporting that they've gained new insight into how that works.

These fortunate patients, known as "elite controllers" or "long-term non-progressors," are quite rare. They've long fascinated scientists who want to understand the secrets lurking inside their immune cells. Researchers trying to develop an AIDS vaccine are especially interested in these special patients.

The key seems to be that certain cells in the immune systems of these people are better able to detect and kill cells that are infected with HIV, the virus that causes AIDS, said study co-author Dr. Bruce Walker, a professor at Harvard School of Public Health.

In essence, he said, they have better "glasses" than the same cells in patients who can't fight off the virus as well. These cells are better able to "see" signs of trouble from infected cells that send out a kind of distress signal.

The new research shows that "there's a way to measure what's good vision and what's bad vision," Walker said. "We can immediately start looking at vaccine candidates to see if our techniques of training these killer cells are leading to really good vision or not. We can also try to understand what it is that's impaired the vision in some of these patients and allowed for good vision to develop in others."

The researchers came to their conclusions after studying the blood of five "elite controllers" and five normal HIV patients.
Only about one in 200 or 300 HIV patients is able to naturally keep the virus from developing into AIDS without the help of medications, Walker noted. One person has been fending off AIDS since 1978.
"We can't be sure that everybody who achieves this state is actually going to persist in it, but it certainly looks like the vast majority of them will," he said.
Nitin Saksena, head of the retroviral genetics division at Westmead Millennium Institute's Center for Virus Research in Sydney, Australia, said the study needs to be confirmed by other research, and it has limitations, such as the small number of patients involved. It's important to consider that "elite controllers" are quite different from each other, Saksena added.

Dr. Mark Connors, chief of the HIV-specific immunity section with the Laboratory of Immunoregulation of the U.S. National Institute of Allergy and Infectious Diseases, questioned the study results, saying they don't demonstrate why the killer immune cells work more effectively in the elite controllers. Essentially, Connors doesn't think the study authors discovered why the cells have better "vision."

Study co-author Walker, however, said the research is valuable: "This is another example of HIV revealing its secrets. Having been in this field for 30 years, the remarkable thing is that we just keep learning more."

The study is published in the June 10 online edition of Nature Immunology.

by Randy Dotinga




Related news items:
Newer news items:
Older news items:

Add comment


Security code
Refresh

380 aspiring fire officers take qualifying exams

21 Nov 2017 Hits:39 Be the first to comment!

More or less 380 applicants took the qualifying exam conducted by the Bureau of Fire Protection (BFP-IX) at the Zamboanga State College of Marine Sciences and Technology, yesterday. District Fire Marshal, CI Clint Cha facilitated the tests and said that the Qualifying Examination is for different ranks from Fire Officer 2 (FO2) to Senior Fire Officer 4 (SFO4) coming from the different cities and municipalities. He added that they took the examinations hoping to be included in the 300 quota for the entire Region-IX. BFP officials said the recruitment is aimed to address the lacking number of fire fighters. In case they will pass the exams, then their date of appointment to the higher post and oath taking will be on December 15, 2017. “This [...] Read more

Prev Next Page:

Cops, probers undergo training on drug cases

21 Nov 2017 Hits:38 Be the first to comment!

Members of the local police, investigators and other law enforcement agencies undergo a two-day enhancement training on handling drug cases in a bid to ensure successful implementation of the war [...] Read more


Submarine cable landing stations to speed-up internet connectivity – DOST

21 Nov 2017 Hits:63 Be the first to comment!

The slow internet connection in the country may soon be a thing of the past. This was according to the Department of Science and Technology (DOST) as it welcomed the [...] Read more


LADY PANTHER WRESTLER… ERICA

20 Nov 2017 Hits:58 Be the first to comment!

Este si Erica Bataclan Martinez, su palayao “Ecang”, 17 años , 5’3” el altor,    Su mayores si Oscar B. Martinez y Lariza A. Bataclan Martinez, su hermano y hermana [...] Read more


FOOTBALL CHIEF… TENG

19 Nov 2017 Hits:52 Be the first to comment!

Este si VICENTE EDUARDO S. TORRES, ta llama conele “Teng/Pardz/Boboy”, 62 años de edad , casao y su esposa si Esther Facultad Torres Y diila anak si Pompeyo F. Torres [...] Read more


AboitizPower sustains strong foothold in hydropower business

18 Nov 2017 Hits:121 Be the first to comment!

On the back of a strong demand for renewable energy (RE), AboitizPower continues to ramp up its portfolio of generation facilities across the Philippines. AboitizPower's subsidiary, SN AboitizPower, has completed the [...] Read more


ZAMBOANGA FOOTBALL - ROLL D BALL

18 Nov 2017 Hits:68 Be the first to comment!

Del Nov. 12, 2017 Domingo el Segundo semana de Season long Zamboanga Football league. El primer juego tan feature cun Resto del Mundo contra  Zamboanga United . Ta pricura man [...] Read more


Police shift war on drugs to anti-gun-for-hire drive

17 Nov 2017 Hits:82 Be the first to comment!

Police regional director and vice chair of the Regional Peace and Order Council (RPOC) for Western Mindanao Chief Supt. Billy Beltran announced recently that all police operatives previously assigned in [...] Read more


Military launch rescue ops for latest victims of ASG

17 Nov 2017 Hits:112 Be the first to comment!

Government troops are now conducting operations to rescue the six people, including two children, who have been abducted by about 15 suspected Abu Sayyaf bandits in Patikul, Sulu, according to [...] Read more


OCENR sets city-wide clean up on Nov 25

17 Nov 2017 Hits:60 Be the first to comment!

The City Government through the Office of the City Environment and Natural Resources (OCENR) will head a city-wide clean up drive on November 25. “We are going to have a city-wide [...] Read more


2017 MUAY THAI NATIONAL CHAMPIONSHIPS

17 Nov 2017 Hits:76 Be the first to comment!

Este si Leo Gandy Serrano, 15 años , Grade 10 na Claret High School Ciudad de Zamboanga . Ya principia juga Muay Thai cuando Grade 5 ele , producto le [...] Read more


Zambopen PWDs endorse Kahil as AVRC III head

16 Nov 2017 Hits:79 Be the first to comment!

The Persons with Disabilities (PWDs) in Zamboanga Peninsula as represented by their chosen leaders have strongly endorsed Zamboangueno Teddy Kahil as head of the Area Vocational Rehabilitation Center (AVRC) in [...] Read more


City SWM Board meet set today

16 Nov 2017 Hits:79 Be the first to comment!

The City Solid Waste Management Board will meet today, November 16, to prepare for the full implementation of the solid waste management ordinance in the City slated on November 27. According [...] Read more


BAP BASKETBALL TOURNAMENTS AND ACTIVITIES

16 Nov 2017 Hits:65 Be the first to comment!

Venue : Southern west campus Gym, San Jose Gusu. Category 40 and 50 years old Master division. Team Standing:    WIN         LOSS J VINCE            [...] Read more


Phil. Coast Guard SWM joins clean-up drive

15 Nov 2017 Hits:76 Be the first to comment!

The Philippine Costal Guard Auxiliary SWM, a volunteer organization, joined the International Costal Clean-up drive (ICC 2017) last recently from 5:00 in the morning to 12:00 noon along the coastal [...] Read more


Mendicants rounded up by the CSWDO

15 Nov 2017 Hits:114 Be the first to comment!

At least 266 mendicants and vagrants were rescued from the various streets of the city proper by the newly created Task Force Mendicants, according to Assistant Social Welfare Officer Dr. [...] Read more


GOLDEN BOY SWIMMER…. GRANT VINCCI

15 Nov 2017 Hits:73 Be the first to comment!

Juego de Zamboanga 2017 Swimming Elementary boys, MVP – GRANT VINCCI VILLANUEVA , Grade 6 na Ateneo de Zamboanga University . Ya saka el 5 Gold medalla na 5 individual [...] Read more


15TH LANUZA SURFING FESTIVAL WINNERS ANNOUNCED

14 Nov 2017 Hits:284 Be the first to comment!

Doot Poktoy, Lanuza Surigao Del Sur Philippines– After almost a week long of festivities, the 15th Lanuza Surfing Festival announces Neil Sanchez (Baler), Mark Aguila (Baler), Daisy Valdez (La Union), [...] Read more


Seven hurt in three road mishaps

14 Nov 2017 Hits:113 Be the first to comment!

Seven people were injured in three separate road accidents in Barangays Buenavista and Talisayan, Zamboanga City over the weekend. In Sitio Buntot, Buenavista, an 11-year-old pedestrian identified as Reynalyn Rodriguez y [...] Read more